The human nasal airway is the first line of defense against airborne pathogens, and it is often the site of debilitating disorders such as asthma and rhinitis. Physiologically relevant models of the nasal airway are essential to understanding how these diseases develop, but many current models lack important dynamic conditions (such as breathing) which affect cellular function.

 

Our nasal airway-on-chip platform  can mimic the breathing airway. Using this dynamic platform, we can study how airflow affects cell behavior and investigate how healthy and diseased nasal airways are impacted by airborne particulates.