CoCo Chip (Co-cultured Cardiomyocytes on Chip) is a patented heart muscle-on-chip platform that allows researchers to non-invasively track and measure heart muscle cell contractility. The technology features a piezoelectric sensing mechanism that converts the mechanical energy of beating heart cells into electrical signals, providing quantitative measurements of contractile force.

This innovative platform incorporates a piezoelectric-polydimethylsiloxane (PE-PDMS) material as a base layer on which cardiac cells are cultured. When the heart cells contract, they cause micro-cantilevers to move, generating measurable electrical signals through the PE-PDMS. This allows researchers to monitor heart muscle function without invasive procedures or complex imaging setups.

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CoCo Chip is designed to create a more physiologically relevant environment for studying heart tissue compared to traditional cell culture methods. It enables researchers to screen drugs, evaluate cardiac treatments, study disease progression, and potentially develop personalized treatment strategies for various heart conditions across diverse genetic backgrounds.